Research Articles
Statistical Validation of Pairwise and High-Order Brain Connectivity: Methods, Applications, and Clinical Translation
This article provides a comprehensive resource for researchers and drug development professionals on the statistical validation of brain functional connectivity.
Beyond Pairwise Connections: How Higher-Order Connectomics is Revolutionizing Our Understanding of Human Brain Function
Moving beyond traditional pairwise models of brain connectivity, higher-order connectomics captures complex interactions among three or more brain regions simultaneously.
Brain Fingerprinting: Unlocking Single-Subject Functional Connectivity for Personalized Medicine
This article explores the paradigm of single-subject brain functional connectivity fingerprinting, a revolutionary approach that identifies individuals based on their unique patterns of neural wiring.
Validating Brain Signatures Across Multiple Cohorts: A Roadmap for Robust Biomarker Development in Neuroscience
This article provides a comprehensive framework for the development and validation of brain signatures as reliable biomarkers across independent cohorts—a critical step for their translation into clinical and research applications.
Leverage Scores for Robust Neural Signatures: A New Frontier in Precision Neuroscience and Biomarker Discovery
This article explores the transformative potential of leverage score sampling, a computational technique from randomized linear algebra, for identifying robust and individual-specific neural signatures from functional connectomes.
Computing Data-Driven Signatures for Behavioral Outcomes: A Comprehensive Guide for Biomedical Research
This article provides a comprehensive framework for researchers and drug development professionals on the creation, application, and validation of data-driven brain signatures as biomarkers for behavioral outcomes.
Decoding Brain Anatomy from Neural Spike Trains: A New Frontier in Neural Coding and Biomedical Research
This article synthesizes recent breakthroughs demonstrating that individual neurons embed robust signatures of their anatomical location within their spike trains—a fundamental and generalizable dimension of the neural code.
Beyond Pairwise Connections: How Higher-Order Brain Network Interactions Are Revolutionizing Neuroscience and Drug Development
This article provides a comprehensive overview of Higher-Order Interactions (HOIs) in brain networks, a paradigm shift beyond traditional pairwise connectivity.
Mapping the Mind: A Computational and Clinical Guide to Brain Region Specialization and Cognitive Function
This article provides a comprehensive synthesis for researchers and drug development professionals on the specialized cognitive functions of key brain regions, integrating foundational neuroanatomy with cutting-edge methodological approaches.
Spatial Overlap Frequency Maps and Consensus Signatures: A New Paradigm for Robust Biomarker and Drug Target Discovery
This article explores the transformative potential of spatial overlap frequency maps and consensus signature methodologies in biomedical research and drug development.