Research Articles
Signature Models vs. Theory-Based Models: A Comprehensive Guide for Drug Development
This article provides a systematic comparison of data-driven signature models and mechanism-driven theory-based models in biomedical research and drug development.
Age-Resilient Neural Signatures: Identifying Stable Biomarkers to Decode Healthy Brain Aging and Neurodegeneration
This article provides a comprehensive resource for researchers and drug development professionals on the identification and validation of age-resilient neural signature biomarkers.
Optimizing Feature Selection with Leverage Score Sampling: Advanced Strategies for High-Dimensional Biomedical Data
This article explores the integration of leverage score sampling with established feature selection paradigms to address critical challenges in high-dimensional biomedical data analysis, particularly in pharmaceutical drug discovery.
Interpreting the Black Box: Challenges, Methods, and Best Practices for Machine Learning in Biomedicine
The adoption of complex machine learning (ML) and deep learning (DL) models in biomedical research and drug development is hampered by their 'black box' nature, where internal decision-making processes are...
Statistical Validation of Single-Subject Brain Connectivity: Methods, Challenges, and Clinical Applications
This article provides a comprehensive framework for the statistical validation of brain connectivity measures at the single-subject level, a critical requirement for personalized diagnostics and treatment monitoring in clinical neuroscience...
The Inflation Problem: Why Small Discovery Sets Undermine Replicability in Scientific Research
This article examines a critical challenge in modern research: the inflation of effect sizes in small discovery datasets and its detrimental impact on replicability.
Spatial Extent Replicability: Overcoming Model Fit Challenges in Biomedical Research and Drug Development
This article addresses the critical challenge of ensuring the replicability of model fit across varying spatial extents, a pivotal concern for researchers and drug development professionals.
Overcoming the Pitfalls in Reproducible Brain-Phenotype Signatures: A Roadmap for Researchers and Drug Developers
This article provides a comprehensive framework for establishing reproducible brain-phenotype signatures, a critical challenge in neuroscience and neuropharmacology.
Individual-Specific Brain Signatures: Unlocking Stable Neural Fingerprints for Precision Medicine and Drug Development
This article synthesizes current research on individual-specific brain parcellations and their stability, a frontier in neuroscience with profound implications for precision medicine and pharmaceutical development.
Systematic Comparison of Interpretable Whole-Brain Dynamics Signatures: A New Framework for Biomarker Discovery and Clinical Translation
This article presents a comprehensive framework for the systematic extraction and comparison of interpretable signatures from whole-brain dynamics, moving beyond limited, manually-selected statistical properties.