Research Articles
Brain Network Dysfunction in Psychopathology: From Circuits to Clinics
This article synthesizes current research on brain network neuroscience and its critical applications in understanding psychopathology.
Robust Brain Signatures for Behavioral Outcomes: A Framework for Statistical Validation in Clinical Research and Drug Development
This article provides a comprehensive framework for developing and validating data-driven brain signatures that reliably predict behavioral outcomes.
Neural Circuits of Remembering: Linking Episodic Memory Systems to Everyday Cognitive Function
This article synthesizes current cognitive neuroscience research on the neural substrates of episodic memory and their critical role in everyday cognition.
Neurobiological and Psychological Foundations of Emotion Regulation for Resilience in Extreme Environments
This article synthesizes contemporary research on the psychological and neurobiological mechanisms through which emotion regulation fosters resilience in extreme and isolated, confined environments (ICEs).
Affordances and Cognitive Capital: A Behavioral Neuroscience Framework for Brain Health and Drug Development
This article synthesizes the behavioral neuroscience of affordances—environmental opportunities for action—with the concept of cognitive capital, the neural and cognitive resources that support adaptive behavior.
Environmental Enrichment: Mechanisms and Therapeutic Potential in Dendritic Remodeling and Adult Neurogenesis
This article synthesizes current research on the profound impacts of environmental enrichment (EE) on brain plasticity, specifically focusing on dendritic branching and neurogenesis.
Neuroplasticity in Behavioral Adaptation and Optimal Performance: Mechanisms, Applications, and Therapeutic Frontiers
This article synthesizes current research on neuroplasticity to provide a comprehensive framework for understanding its role in behavioral adaptation and the pursuit of optimal performance.
Neural Mechanisms of Cognitive Reserve: From Brain Networks to Therapeutic Interventions
This comprehensive review examines the neural implementation of cognitive reserve (CR) and its implications for maintaining brain performance against aging and neurodegeneration.
Beyond Memory: The Hippocampus as a Dynamic Hub in Stress Response and Adaptive Decision-Making
This article synthesizes contemporary research on the multifaceted role of the hippocampus, moving beyond its traditional association with memory to explore its critical functions in stress regulation and adaptive decision-making. We examine the neurobiological mechanisms through which stress alters hippocampal structure and function, including synaptic plasticity and neuronal excitability, and how these changes impact behavior. The review further explores the hippocampus's contribution to model-based decision-making, spatial representation, and social learning through its interactions with prefrontal-striatal circuits. By integrating foundational knowledge with current methodological approaches, troubleshooting insights, and comparative validations, this article provides a comprehensive resource for researchers and drug development professionals aiming to understand and target hippocampal-centered pathways in neuropsychiatric disorders.
The Mindful Machine: How Predictive Brains Could Revolutionize Robot Caregiving
Exploring how brain-inspired predictive processing is creating a new generation of flexible, adaptive caregiving robots for an aging world.